Ractopamine effects β-1 and β-2 adrenergic receptor gene expression in fat and muscle tissue of boars and gilts
Document Type
Conference Proceeding
Publication Date
2011
Conference Title
Thirteenth Biennial Conference of the Australasian Pig Science Association
Place of Publication
Adelaide
ISBN
978-0-9806880-1-6
ISSN
1324 9177
Keywords
pigs, swine
Disciplines
Animal Sciences | Meat Science
Abstract
Dietary ractopamine (RAC) reduces fat mass due to direct activation of β-adrenergic receptors (βAR) in adipocytes promoting triglyceride hydrolysis and decreasing fatty acid and triglyceride synthesis leading to less lipid accumulation (Mills, 2002). Fat accretion in pigs fed RAC is not consistently reduced (Dunshea, 1993) which may result from irregularities in βAR down-regulation. Dietary RAC consistently improves lean deposition in pigs in the first two weeks of treatment after which response begins to decline, this may be because down-regulation of βAR in skeletal muscle is either not significant or delayed (Mills, 2002). It is not clear whether down regulation of the βAR in fat or muscle tissue is affected by dose of RAC and whether there are notable sex differences. The aim of the experiment was to determine the effect of RAC dose, duration of treatment, or sex effect on βAR gene subtype expression in fat or muscle tissue.
Recommended Citation
Rikard-Bell, C V,
Nattrass, G,
Pluske, J R,
van Barneveld, R J,
Mullan, B P,
Edwards, A C,
Gannon, N J,
Henman, D J,
and
Dunshea, F R.
(2011), Ractopamine effects β-1 and β-2 adrenergic receptor gene expression in fat and muscle tissue of boars and gilts, Thirteenth Biennial Conference of the Australasian Pig Science Association, Adelaide, pp.90-90.
https://library.dpird.wa.gov.au/conf_papers/127
