Dietary vitamin E and aspirin supplementation influence the performance and incidence of post-weaning colibacillosis in pigs experimentally infected with an enterotoxigenic strain of Escherichia coli

Document Type

Conference Proceeding

Publication Date

11-2013

Conference Title

Manipulating Pig Production XIV

Place of Publication

Werribee

ISBN

978-0-9806880-3-0

ISSN

1324 9177

Keywords

pigs, swine, E. coli

Disciplines

Animal Sciences | Meat Science

Abstract

Increased biosynthesis of prostaglandin E2 (PGE2) from arachidonic acid, caused by immune system activation, negatively affects the performance and health of pigs (Wright et al., 2000). Xu et al. (1990) reported that supplementation of 125 ppm aspirin, an anti-inflammatory agent, improved the daily gain and feed conversion ratio of weaner pigs. Furthermore, in chickens, a combined supplementation of aspirin and vitamin E (Vit E) synergistically depressed PGE2 biosynthesis and reduced mortalities after an E. coli infection (Likoff et al., 1981). The current experiment tested the hypothesis that Vit E and aspirin supplementation would have a synergistic effect on reducing post-weaning colibacillosis (PWC) and improving performance in pigs experimentally infected with an enterotoxigenic strain of E. coli (ETEC)

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